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烟酰胺单核苷酸能够增加糖尿病前期妇女的肌肉胰岛素敏感性
作者:小柯机器人 发布时间:2021/4/25 14:51:07

美国神路易斯华盛顿大学Samuel Klein研究组发现,烟酰胺单核苷酸能够增加糖尿病前期妇女的肌肉胰岛素敏感性。2021年4月22日,国际知名学术期刊《科学》在线发表了这一成果。

研究人员进行了一项为期10周的随机、安慰剂对照的双盲试验,来评估补充烟酰胺单核苷酸(NMN)对绝经后患有超重或肥胖妇女的女性代谢功能的影响。补充NMN后,胰岛素刺激的葡萄糖处置和骨骼肌胰岛素信号(AKT和mTOR的磷酸化)增加,但安慰剂治疗后未改变。NMN补充上调了血小板衍生的生长因子受体β和其他与肌肉重塑相关的基因表达。这些结果表明,NMN可增加超重或肥胖的糖尿病前期妇女的肌肉胰岛素敏感性、胰岛素信号传导和重塑。

据介绍,在啮齿动物中,肥胖和衰老会损害烟酰胺腺嘌呤二核苷酸(NAD+)的生物合成,从而导致代谢功能障碍。NMN的可用性是哺乳动物NAD+生物合成中的限速因素。

附:英文原文

Title: Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Author: Mihoko Yoshino, Jun Yoshino, Brandon D. Kayser, Gary Patti, Michael P. Franczyk, Kathryn F. Mills, Miriam Sindelar, Terri Pietka, Bruce W. Patterson, Shin-Ichiro Imai, Samuel Klein

Issue&Volume: 2021/04/22

Abstract: In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+) biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide (NMN) availability is a rate-limiting factor in mammalian NAD+ biosynthesis. We conducted a 10-week, randomized, placebo-controlled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who were overweight or obese. Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling (phosphorylation of AKT and mTOR) increased after NMN supplementation, but did not change after placebo treatment. NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate NMN increases muscle insulin sensitivity, insulin signaling and remodeling in women with prediabetes who are overweight or obese (ClinicalTrial.gov NCT 03151239).

DOI: 10.1126/science.abe9985

Source: https://science.sciencemag.org/content/early/2021/04/21/science.abe9985

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037