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科学家在阿尔茨海默氏病中发现了四种不同的tau沉积轨迹
作者:小柯机器人 发布时间:2021/4/30 22:00:02

瑞典隆德大学Oskar Hansson、加拿大麦吉尔大学Jacob W. Vogel等研究人员合作在阿尔茨海默氏病中发现了四种不同的tau沉积轨迹。该项研究成果于2021年4月29日在线发表在《自然—医学》杂志上。

使用来自1,612位个体的tau正电子发射断层扫描,研究人员确定了tau病理的4种不同时空轨迹,患病率从18%到33%不等。研究人员重复了先前描述的边缘为主和内侧颞叶保留模式,同时还发现了类似于阿尔茨海默氏病(AD)的非典型临床变异的后颞侧模式。这些“亚型”在纵向随访期间是稳定的,并使用不同的放射性示踪剂在单独的样品中重现。亚型表现出不同的人口统计学和认知特征以及不同的纵向结果。此外,网络扩散模型暗示病理学通过不同亚型的不同皮质寡聚体网络来起源和传播。

总之,这些结果表明,tau病理学的变化是普遍且系统的,也许值得对“典型AD”的概念进行重新审查,并重新审视tau病理学分期。

据悉,AD的特征是tau病理在整个大脑皮层中扩散。尽管最近的研究表明患有AD的人群存在很大的变异性,但人们认为这种传播方式在个体之间是相当一致的。

附:英文原文

Title: Four distinct trajectories of tau deposition identified in Alzheimer’s disease

Author: Jacob W. Vogel, Alexandra L. Young, Neil P. Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T. Strandberg, Renaud La Joie, Leon M. Aksman, Michel J. Grothe, Yasser Iturria-Medina, Michael J. Pontecorvo, Michael D. Devous, Gil D. Rabinovici, Daniel C. Alexander, Chul Hyoung Lyoo, Alan C. Evans, Oskar Hansson

Issue&Volume: 2021-04-29

Abstract: Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging.

DOI: 10.1038/s41591-021-01309-6

Source: https://www.nature.com/articles/s41591-021-01309-6

 

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex