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颅骨和脊椎骨髓是脑膜和中枢神经系统实质的髓样细胞库
作者:小柯机器人 发布时间:2021/6/6 21:40:40

德国美因茨大学Jonathan Kipnis小组发现,颅骨和脊椎骨髓是脑膜和中枢神经系统实质的髓样细胞库。这一研究成果于2021年6月3日在线发表在国际学术期刊《科学》上。

研究人员发现,脑膜包含一类单核细胞和中性粒细胞,它们不是由血液提供的,而是由相邻的颅骨和脊椎骨髓提供的。在病理条件下,包括脊髓损伤和神经炎症,中枢神经系统浸润的髓样细胞可以起源于大脑边界,并显示出与其血液来源的对应细胞不同的转录特征。因此,中枢神经系统边界由来自相邻骨髓微环境的骨髓细胞所定居,并在稳态和病理条件下提供先天免疫细胞。

这些发现表明,人们需要重新解释在损伤和自身免疫过程中浸润到中枢神经系统的免疫细胞,并可能为未来利用脑膜免疫细胞的治疗方法提供信息。

据介绍,脑膜是包裹中枢神经系统(CNS)的膜状结构,其中包含丰富的免疫细胞库,并介导CNS中的免疫监视。 

附:英文原文

Title: Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Author: Andrea Cugurra, Tornike Mamuladze, Justin Rustenhoven, Taitea Dykstra, Giorgi Beroshvili, Zev J. Greenberg, Wendy Baker, Zach Papadopoulos, Antoine Drieu, Susan Blackburn, Mitsuhiro Kanamori, Simone Brioschi, Jasmin Herz, Laura G. Schuettpelz, Marco Colonna, Igor Smirnov, Jonathan Kipnis

Issue&Volume: 2021/06/03

Abstract: The meninges are a membranous structure enveloping the central nervous system (CNS) that host a rich repertoire of immune cells mediating CNS immune surveillance. Here, we report that the meninges contain a pool of monocytes and neutrophils supplied not from the blood, but by adjacent skull and vertebral bone marrow. Under pathological conditions, including spinal cord injury and neuroinflammation, CNS-infiltrating myeloid cells can originate from brain borders and display transcriptional signatures distinct from their blood-derived counterparts. Thus, CNS borders are populated by myeloid cells from adjacent bone-marrow niches, strategically placed to supply innate immune cells under homeostatic and pathological conditions. These findings call for reinterpretation of immune-cell infiltration into the CNS during injury and autoimmunity and may inform future therapeutic approaches harnessing meningeal immune cells.

DOI: 10.1126/science.abf7844

Source: https://science.sciencemag.org/content/early/2021/06/02/science.abf7844

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037